A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy.

Placzek, W J; Wei, J; Kitada, S; Zhai, D; Reed, J C; Pellecchia, M

Placzek, W J; Wei, J; Kitada, S; Zhai, D; Reed, J C; Pellecchia, M.

Affiliation

Placzek WJ; Sanford/Burnham Medical Research Institute, La Jolla, CA 92037, USA.

Cell Death Dis ; 1: e40, 2010 May 06.

Article in En | MEDLINE | ID: mdl-21364647

Subject(s)

Apoptosis; Neoplasms/drug therapy; Neoplasms/genetics; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors; Proto-Oncogene Proteins c-bcl-2/genetics; Apoptosis/drug effects; Apoptosis/genetics; Cell Line, Tumor; Fluorescence Polarization; Gene Expression Regulation, Neoplastic/drug effects; Humans; Models, Biological; Neoplasms/classification; Neoplasms/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Small Molecule Libraries/chemistry; Small Molecule Libraries/pharmacology; Small Molecule Libraries/therapeutic use; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Proto-Oncogene Proteins c-bcl-2 / Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Cell Death Dis Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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