Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment.

Judson, Richard S; Kavlock, Robert J; Setzer, R Woodrow; Hubal, Elaine A Cohen; Martin, Matthew T; Knudsen, Thomas B; Houck, Keith A; Thomas, Russell S; Wetmore, Barbara A; Dix, David J

Judson, Richard S; Kavlock, Robert J; Setzer, R Woodrow; Hubal, Elaine A Cohen; Martin, Matthew T; Knudsen, Thomas B; Houck, Keith A; Thomas, Russell S; Wetmore, Barbara A; Dix, David J.

Affiliation

Judson RS; National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. judson.richard@epa.gov

Chem Res Toxicol ; 24(4): 451-62, 2011 Apr 18.

Article in En | MEDLINE | ID: mdl-21384849

Subject(s)

High-Throughput Screening Assays; Toxicity Tests/methods; Benzhydryl Compounds; Dose-Response Relationship, Drug; Humans; Metabolic Networks and Pathways/drug effects; Pharmacokinetics; Phenols/pharmacokinetics; Phenols/toxicity; Risk Assessment; Triazoles/pharmacokinetics; Triazoles/toxicity; Uncertainty

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toxicity Tests / High-Throughput Screening Assays Type of study: Etiology_studies / Guideline / Risk_factors_studies Limits: Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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