Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques.

Waldmann, Thomas A; Lugli, Enrico; Roederer, Mario; Perera, Liyanage P; Smedley, Jeremy V; Macallister, Rhonda P; Goldman, Carolyn K; Bryant, Bonita R; Decker, Jean M; Fleisher, Thomas A; Lane, H Clifford; Sneller, Michael C; Kurlander, Roger J; Kleiner, David E; Pletcher, John M; Figg, William D; Yovandich, Jason L; Creekmore, Stephen P

Waldmann, Thomas A; Lugli, Enrico; Roederer, Mario; Perera, Liyanage P; Smedley, Jeremy V; Macallister, Rhonda P; Goldman, Carolyn K; Bryant, Bonita R; Decker, Jean M; Fleisher, Thomas A; Lane, H Clifford; Sneller, Michael C; Kurlander, Roger J; Kleiner, David E; Pletcher, John M; Figg, William D; Yovandich, Jason L; Creekmore, Stephen P.

Affiliation

Waldmann TA; Center for Cancer Research, National Cancer Institute, Frederick, MD, USA. tawald@helix.nih.gov

Blood ; 117(18): 4787-95, 2011 May 05.

Article in En | MEDLINE | ID: mdl-21385847

Subject(s)

Interleukin-15/toxicity; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/immunology; Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/toxicity; Blood Coagulation/drug effects; Bone Marrow/drug effects; Bone Marrow/pathology; Humans; Immunotherapy; Infusions, Intravenous; Interleukin-15/administration & dosage; Interleukin-15/immunology; Interleukin-15/pharmacokinetics; Liver/drug effects; Liver/pathology; Macaca mulatta; Neoplasms/immunology; Neoplasms/therapy; Neutropenia/blood; Neutropenia/chemically induced; Recombinant Proteins/administration & dosage; Recombinant Proteins/immunology; Recombinant Proteins/pharmacokinetics; Recombinant Proteins/toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-15 Limits: Animals / Humans Language: En Journal: Blood Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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