Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency.
Hum Brain Mapp
; 33(1): 143-53, 2012 Jan.
Article
in En
| MEDLINE
| ID: mdl-21391259
ABSTRACT
BACKGROUND:
The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder.AIMS:
To examine the influence of G72 variation on brain function in the healthy population.METHOD:
Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes.RESULTS:
G72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P < 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P < 0.05).CONCLUSIONS:
Our results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Verbal Behavior
/
Brain
/
Carrier Proteins
/
Glutamic Acid
/
Polymorphism, Single Nucleotide
Limits:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Hum Brain Mapp
Journal subject:
CEREBRO
Year:
2012
Document type:
Article
Affiliation country:
United kingdom