Antibodies/metabolism; Antineoplastic Agents/pharmacology; Endostatins/metabolism; Recombinant Fusion Proteins/pharmacology; Amino Acid Substitution; Angiogenesis Inhibitors/metabolism; Angiogenesis Inhibitors/pharmacology; Animals; Antibodies/genetics; Antibodies/immunology; Antineoplastic Agents/metabolism; Area Under Curve; Cell Line; Cell Line, Tumor; Cell Proliferation/drug effects; Endostatins/genetics; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Female; Humans; Mammary Neoplasms, Experimental/drug therapy; Mammary Neoplasms, Experimental/metabolism; Mammary Neoplasms, Experimental/pathology; Mice; Mice, Inbred BALB C; Mice, SCID; Mutant Proteins/genetics; Mutant Proteins/metabolism; Mutation; Rabbits; Receptor, ErbB-2/immunology; Recombinant Fusion Proteins/metabolism; Recombinant Fusion Proteins/pharmacokinetics; Tumor Burden/drug effects; Xenograft Model Antitumor Assays