Novel potential markers of nasopharyngeal carcinoma for diagnosis and therapy.
Clin Biochem
; 44(8-9): 711-8, 2011 Jun.
Article
in En
| MEDLINE
| ID: mdl-21402064
ABSTRACT
OBJECTIVE:
To search for markers of nasopharyngeal carcinoma (NPC) for diagnosis. DESIGN ANDMETHODS:
Using gas chromatography and mass spectrometry, we evaluated 51 serum metabolites in 49 NPC, 37 throat cancer patients and 40 healthy controls. High metabolites were selected and confirmed in NPC tissues. Sensitivity and specificity were appraised for 53 NPC diagnoses.RESULTS:
Metabolic profiling revealed that kynurenine, N-acetylglucosaminylamine, N-acetylglucosamine and hydroxyphenylpyruvate increased in NPC patient sera. Their sensitivity and specificity were respectively 79% and 71%, 78% and 69%, 83% and 68%, 84% and 73% for NPC diagnosis. These increases were confirmed in NPC cells. Four metabolites gradually increased from stage I to stage III. After radiotherapy, four metabolites decreased gradually, and tended to a normal level, and were associated with rate of tumor reduction.CONCLUSION:
The results reveal that kynurenine, N-acetylglucosaminylamine, N-acetylglucosamine and hydroxyphenylpyruvate are potentially markers of NPC for diagnosis and therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biomarkers, Tumor
/
Nasopharyngeal Neoplasms
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Clin Biochem
Year:
2011
Document type:
Article