Intranasal immunization with poly(Î³-glutamic acid) nanoparticles entrapping antigenic proteins can induce potent tumor immunity.

Matsuo, Keisuke; Koizumi, Hayato; Akashi, Mitsuru; Nakagawa, Shinsaku; Fujita, Takuya; Yamamoto, Akira; Okada, Naoki

Matsuo, Keisuke; Koizumi, Hayato; Akashi, Mitsuru; Nakagawa, Shinsaku; Fujita, Takuya; Yamamoto, Akira; Okada, Naoki.

Affiliation

Matsuo K; Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

J Control Release ; 152(2): 310-6, 2011 Jun 10.

Article in En | MEDLINE | ID: mdl-21402114

Subject(s)

Cancer Vaccines/administration & dosage; Drug Carriers/chemistry; Nanoparticles/chemistry; Neoplasms/prevention & control; Ovalbumin/administration & dosage; Polyglutamic Acid/analogs & derivatives; Administration, Intranasal; Animals; Cancer Vaccines/immunology; Cancer Vaccines/pharmacokinetics; Cancer Vaccines/therapeutic use; Cell Line, Tumor; Female; Humans; Immunization; Immunoglobulin G/blood; Immunoglobulin G/immunology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neoplasms/immunology; Ovalbumin/immunology; Ovalbumin/pharmacokinetics; Ovalbumin/therapeutic use; Polyglutamic Acid/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyglutamic Acid / Drug Carriers / Ovalbumin / Cancer Vaccines / Nanoparticles / Neoplasms Limits: Animals / Female / Humans Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2011 Document type: Article Affiliation country: Japan Country of publication: Netherlands

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