Development and validation of efficient stable isotope dilution LC-HESI-MS/MS method for the verification of ß-lyase metabolites in human urine after sulfur mustard exposure.

Halme, Mia; Karjalainen, Maaret; Kiljunen, Harri; Vanninen, Paula

Halme, Mia; Karjalainen, Maaret; Kiljunen, Harri; Vanninen, Paula.

Affiliation

Halme M; VERIFIN, Finnish Institute for Verification of the Chemical Weapons Convention, Department of Chemistry, University of Helsinki, Helsinki, Finland. mia.halme@helsinki.fi

J Chromatogr B Analyt Technol Biomed Life Sci ; 879(13-14): 908-14, 2011 Apr 15.

Article in En | MEDLINE | ID: mdl-21420367

Subject(s)

Chemical Warfare Agents/pharmacokinetics; Isotope Labeling/methods; Lyases/metabolism; Mustard Gas/pharmacokinetics; Spectrometry, Mass, Electrospray Ionization/methods; Sulfides/urine; Sulfones/urine; Sulfoxides/urine; Analysis of Variance; Biomarkers/metabolism; Biomarkers/urine; Chemical Warfare Agents/analysis; Chemical Warfare Agents/poisoning; Humans; Isotope Labeling/standards; Linear Models; Mustard Gas/analysis; Mustard Gas/poisoning; Poisoning/urine; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization/standards; Sulfides/metabolism; Sulfones/metabolism; Sulfoxides/metabolism; Tandem Mass Spectrometry/methods; Tandem Mass Spectrometry/standards

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfides / Sulfones / Sulfoxides / Chemical Warfare Agents / Spectrometry, Mass, Electrospray Ionization / Isotope Labeling / Lyases / Mustard Gas Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: J Chromatogr B Analyt Technol Biomed Life Sci Journal subject: ENGENHARIA BIOMEDICA Year: 2011 Document type: Article Affiliation country: Finland Country of publication: Netherlands

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