IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.

Eto, Danelle; Lao, Christopher; DiToro, Daniel; Barnett, Burton; Escobar, Tania C; Kageyama, Robin; Yusuf, Isharat; Crotty, Shane

Eto, Danelle; Lao, Christopher; DiToro, Daniel; Barnett, Burton; Escobar, Tania C; Kageyama, Robin; Yusuf, Isharat; Crotty, Shane.

Affiliation

Eto D; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.

PLoS One ; 6(3): e17739, 2011 Mar 14.

Article in En | MEDLINE | ID: mdl-21423809

Subject(s)

B-Lymphocytes/immunology; Cell Differentiation/immunology; Immunity/immunology; Interleukin-6/metabolism; Interleukins/metabolism; T-Lymphocytes, Helper-Inducer/cytology; Animals; B-Lymphocytes/cytology; Germinal Center/cytology; Germinal Center/immunology; Humans; Interleukin-6/deficiency; Interleukins/biosynthesis; Interleukins/deficiency; Lymphocyte Activation/immunology; Mice; Plasma Cells/cytology; Plasma Cells/immunology; T-Lymphocytes, Helper-Inducer/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Cell Differentiation / Interleukins / Interleukin-6 / T-Lymphocytes, Helper-Inducer / Immunity Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Document type: Article Affiliation country: United States

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