Extreme reduction and compaction of microsporidian genomes.
Res Microbiol
; 162(6): 598-606, 2011.
Article
in En
| MEDLINE
| ID: mdl-21426934
ABSTRACT
Microsporidia are fungi-related obligate intracellular parasites with a highly reduced and compact genome, as for Encephalitozoon species which harbor a genome smaller than 3 Mbp. Genome compaction is reflected by high gene density and, for larger microsporidian genomes, size variation is due to repeat elements that do not drastically affect gene density. Furthermore, these pathogens present strong host dependency illustrated by extensive gene loss. Such adaptations associated with genome compaction induced gene size reduction but also simplification of cellular processes such as transcription. Thus, microsporidia are excellent models for eukaryotic genome evolution and gene expression in the context of host-pathogen relationships.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Variation
/
Microsporidia
/
Genome, Fungal
Language:
En
Journal:
Res Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2011
Document type:
Article
Affiliation country:
France