Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

Biava, M; Porretta, G C; Poce, G; Battilocchio, C; Botta, M; Manetti, F; Rovini, M; Cappelli, A; Sautebin, L; Rossi, A; Pergola, C; Ghelardini, C; Galeotti, N; Makovec, F; Giordani, A; Anzellotti, P; Tacconelli, S; Patrignani, P; Anzini, M

Biava, M; Porretta, G C; Poce, G; Battilocchio, C; Botta, M; Manetti, F; Rovini, M; Cappelli, A; Sautebin, L; Rossi, A; Pergola, C; Ghelardini, C; Galeotti, N; Makovec, F; Giordani, A; Anzellotti, P; Tacconelli, S; Patrignani, P; Anzini, M.

Affiliation

Biava M; Dipartimento di Studi di Chimica e Tecnologie del Farmaco, Università "La Sapienza", piazzale Aldo Moro 5, I-00185 Roma, Italy. mariangela.biava@uniroma1.it

Curr Med Chem ; 18(10): 1540-54, 2011.

Article in En | MEDLINE | ID: mdl-21428878

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/chemistry; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Anti-Inflammatory Agents/chemistry; Anti-Inflammatory Agents/pharmacology; Pyrroles/chemistry; Pyrroles/pharmacology; Analgesics/chemistry; Analgesics/pharmacology; Analgesics/therapeutic use; Animals; Anti-Inflammatory Agents/therapeutic use; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use; Cyclooxygenase 1/metabolism; Cyclooxygenase 2/metabolism; Cyclooxygenase Inhibitors/chemistry; Cyclooxygenase Inhibitors/pharmacology; Cyclooxygenase Inhibitors/therapeutic use; Humans; Pyrroles/therapeutic use; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Anti-Inflammatory Agents, Non-Steroidal / Anti-Inflammatory Agents Limits: Animals / Humans Language: En Journal: Curr Med Chem Journal subject: QUIMICA Year: 2011 Document type: Article Affiliation country: Italy Country of publication: United Arab Emirates

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