Protection of pancreatic INS-1 ß-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin.

Lablanche, S; Cottet-Rousselle, C; Lamarche, F; Benhamou, P-Y; Halimi, S; Leverve, X; Fontaine, E

Lablanche, S; Cottet-Rousselle, C; Lamarche, F; Benhamou, P-Y; Halimi, S; Leverve, X; Fontaine, E.

Affiliation

Lablanche S; Inserm, U1055, Grenoble F-38041, France.

Cell Death Dis ; 2: e134, 2011 Mar 24.

Article in En | MEDLINE | ID: mdl-21430707

Subject(s)

Cyclosporine/pharmacology; Fructose/toxicity; Glucose/toxicity; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/metabolism; Metformin/pharmacology; Mitochondria/metabolism; Protective Agents/pharmacology; Animals; Apoptosis/drug effects; Biological Transport/drug effects; Calcium/metabolism; Cell Death/drug effects; Cell Line; Cell Survival/drug effects; Fructose/metabolism; Glucose/metabolism; Insulin-Secreting Cells/drug effects; Permeability/drug effects; Rats

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclosporine / Protective Agents / Insulin-Secreting Cells / Fructose / Glucose / Metformin / Mitochondria Limits: Animals Language: En Journal: Cell Death Dis Year: 2011 Document type: Article Affiliation country: France Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google