Raltegravir: the first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium.
Ann N Y Acad Sci
; 1222: 83-9, 2011 Mar.
Article
in En
| MEDLINE
| ID: mdl-21434946
ABSTRACT
Raltegravir is the first integrase strand transfer inhibitor approved for the treatment of HIV-1 infection. As the first agent in this new class of antiretroviral therapies, raltegravir has demonstrated safety and efficacy in treatment-naive as well as heavily pretreated HIV-infected patients failing therapy with multidrug-resistant virus. Raltegravir has a favorable drug interaction profile that permits both administration to a wide, demographically diverse patient population and coadministration with many other therapeutic agents, including antiretroviral agents and supportive medications, without restrictions or dose adjustment. Data through 96 weeks of follow-up in three phase III studies, protocol 021 (STARTMRK) in treatment-naive patients, and protocols 018 (BENCHMRK-1) and 019 (BENCHMRK-2) in treatment-experienced patients, demonstrated the potent and durable antiretroviral and immunologic effects and the favorable long-term safety profile of raltegravir in both treatment-naive and treatment-experienced patients. Raltegravir represents an important addition to the current armamentarium for the treatment of HIV infection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrrolidinones
/
HIV Infections
/
HIV Integrase Inhibitors
/
Anti-HIV Agents
Type of study:
Evaluation_studies
/
Guideline
Limits:
Humans
Language:
En
Journal:
Ann N Y Acad Sci
Year:
2011
Document type:
Article
Affiliation country:
United States