Normal skin and hypertrophic scar fibroblasts differentially regulate collagen and fibronectin expression as well as mitochondrial membrane potential in response to basic fibroblast growth factor.

Song, Rui; Bian, Hui-Ning; Lai, Wen; Chen, Hua-De; Zhao, Ke-Seng

Song, Rui; Bian, Hui-Ning; Lai, Wen; Chen, Hua-De; Zhao, Ke-Seng.

Affiliation

Song R; Guangdong Key Laboratory of the Shock and Microcirculation Research, Department of Pathophysiology, Southern Medical University, Guangzhou, China.

Braz J Med Biol Res ; 44(5): 402-10, 2011 May.

Article in En | MEDLINE | ID: mdl-21445528

Subject(s)

Cicatrix, Hypertrophic/pathology; Collagen Type III/metabolism; Collagen Type I/metabolism; Fibroblast Growth Factor 2/pharmacology; Fibroblasts/drug effects; Fibronectins/metabolism; Skin/cytology; Cells, Cultured; Cicatrix, Hypertrophic/metabolism; Collagen Type I/ultrastructure; Collagen Type III/ultrastructure; Fibroblasts/metabolism; Fibroblasts/ultrastructure; Fibronectins/ultrastructure; Humans; Membrane Potential, Mitochondrial/drug effects; Membrane Potential, Mitochondrial/physiology; Microscopy, Electron, Transmission; Reverse Transcriptase Polymerase Chain Reaction; Skin/metabolism; Up-Regulation; Wound Healing

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Fibroblast Growth Factor 2 / Fibronectins / Cicatrix, Hypertrophic / Collagen Type I / Collagen Type III / Fibroblasts Limits: Humans Language: En Journal: Braz J Med Biol Res Year: 2011 Document type: Article Affiliation country: China Country of publication: Brazil

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