Exon 11 deletion in the myocyte enhancer factor (MEF)2A and early onset coronary artery disease gene in a Sicilian family.
Eur J Cardiovasc Prev Rehabil
; 18(4): 557-60, 2011 Aug.
Article
in En
| MEDLINE
| ID: mdl-21450604
ABSTRACT
AIMS:
We investigated the prevalence of the myocyte enhancer factor (MEF)2A exon 11 deletion, a putative coronary artery disease (CAD) susceptibility gene, in patients referred for coronary angiography. METHODS ANDRESULTS:
In total, 1079 consecutive patients referred for coronary angiography in the GENICA Study were genotyped and 301 low-risk subjects were used as controls. One patient with early onset three vessels CAD, carrying the MEF2A deletion was found in the GENICA Study cohort and none in the control group.CONCLUSION:
In a cohort of patients undergoing coronary angiography for suspected CAD the MEF2A exon 11 deletion occurred in 0.09%.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronary Artery Disease
/
Gene Deletion
/
Myogenic Regulatory Factors
/
MADS Domain Proteins
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Eur J Cardiovasc Prev Rehabil
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Italy