Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesis.

Pisanti, Simona; Picardi, Paola; Prota, Lucia; Proto, Maria Chiara; Laezza, Chiara; McGuire, Paul G; Morbidelli, Lucia; Gazzerro, Patrizia; Ziche, Marina; Das, Arup; Bifulco, Maurizio

Pisanti, Simona; Picardi, Paola; Prota, Lucia; Proto, Maria Chiara; Laezza, Chiara; McGuire, Paul G; Morbidelli, Lucia; Gazzerro, Patrizia; Ziche, Marina; Das, Arup; Bifulco, Maurizio.

Affiliation

Pisanti S; Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy.

Blood ; 117(20): 5541-50, 2011 May 19.

Article in En | MEDLINE | ID: mdl-21460248

Subject(s)

Neovascularization, Physiologic; Receptor, Cannabinoid, CB1/antagonists & inhibitors; Receptor, Cannabinoid, CB1/deficiency; Animals; Base Sequence; Cell Proliferation/drug effects; Cells, Cultured; Cornea/blood supply; Cornea/drug effects; Disease Models, Animal; Endothelial Cells/cytology; Endothelial Cells/drug effects; Endothelial Cells/physiology; Fibroblast Growth Factor 2/pharmacology; Focal Adhesion Protein-Tyrosine Kinases/metabolism; Gene Knockdown Techniques; Humans; Infant, Newborn; JNK Mitogen-Activated Protein Kinases/metabolism; Matrix Metalloproteinase 2/metabolism; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic/drug therapy; Neovascularization, Physiologic/drug effects; RNA, Small Interfering/genetics; Rabbits; Receptor, Cannabinoid, CB1/genetics; Retinopathy of Prematurity/drug therapy; Signal Transduction; rho-Associated Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neovascularization, Physiologic / Receptor, Cannabinoid, CB1 Type of study: Prognostic_studies Limits: Animals / Humans / Newborn Language: En Journal: Blood Year: 2011 Document type: Article Affiliation country: Italy Country of publication: United States

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