Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.

Lu, Yingjuan; Stinnette, Torian W; Westrick, Elaine; Klein, Patrick J; Gehrke, Mark A; Cross, Vicky A; Vlahov, Iontcho R; Low, Philip S; Leamon, Christopher P

Lu, Yingjuan; Stinnette, Torian W; Westrick, Elaine; Klein, Patrick J; Gehrke, Mark A; Cross, Vicky A; Vlahov, Iontcho R; Low, Philip S; Leamon, Christopher P.

Affiliation

Lu Y; Endocyte, Inc., 3000 Kent Avenue, West Lafayette, IN 47906, USA.

Arthritis Res Ther ; 13(2): R56, 2011 Apr 04.

Article in En | MEDLINE | ID: mdl-21463515

Subject(s)

Aminopterin/analogs & derivatives; Aminopterin/pharmacology; Anti-Inflammatory Agents/pharmacology; Arthritis, Experimental/drug therapy; Folic Acid Antagonists/pharmacology; Folic Acid/analogs & derivatives; Folic Acid/pharmacology; Aminopterin/chemical synthesis; Aminopterin/pharmacokinetics; Animals; Anti-Inflammatory Agents/chemical synthesis; Anti-Inflammatory Agents/pharmacokinetics; Female; Folate Receptors, GPI-Anchored/drug effects; Folic Acid/chemical synthesis; Folic Acid/pharmacokinetics; Folic Acid Antagonists/chemical synthesis; Folic Acid Antagonists/pharmacokinetics; Macrophages/drug effects; Mice; Rats; Rats, Inbred Lew

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Folic Acid / Folic Acid Antagonists / Aminopterin / Anti-Inflammatory Agents Limits: Animals Language: En Journal: Arthritis Res Ther Journal subject: REUMATOLOGIA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

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