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Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer.
De Bacco, Francesca; Luraghi, Paolo; Medico, Enzo; Reato, Gigliola; Girolami, Flavia; Perera, Timothy; Gabriele, Pietro; Comoglio, Paolo M; Boccaccio, Carla.
Affiliation
  • De Bacco F; IRCC-Institute for Cancer Research at Candiolo, University of Turin Medical School, Candiolo, Italy.
J Natl Cancer Inst ; 103(8): 645-61, 2011 Apr 20.
Article in En | MEDLINE | ID: mdl-21464397
Subject(s)
Cell Cycle Proteins/metabolism; DNA Damage/radiation effects; DNA-Binding Proteins/metabolism; NF-kappa B/metabolism; Neoplasms/metabolism; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins c-met/metabolism; Receptors, Growth Factor/antagonists & inhibitors; Receptors, Growth Factor/metabolism; Signal Transduction/radiation effects; Tumor Suppressor Proteins/metabolism; Animals; Apoptosis/radiation effects; Ataxia Telangiectasia Mutated Proteins; Blotting, Northern; Cell Cycle Proteins/genetics; Cell Cycle Proteins/radiation effects; Cell Line, Tumor; Cell Movement/radiation effects; Cell Survival/radiation effects; Chromatin Immunoprecipitation; DNA-Binding Proteins/genetics; DNA-Binding Proteins/radiation effects; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic/drug effects; Gene Silencing; Humans; In Situ Nick-End Labeling; Indoles/pharmacology; Mice; Mitogen-Activated Protein Kinases/metabolism; NF-kappa B/genetics; NF-kappa B/radiation effects; Neoplasm Invasiveness/prevention & control; Neoplasms/pathology; Neoplasms/radiotherapy; Phosphorylation/radiation effects; Polymerase Chain Reaction; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/radiation effects; Proto-Oncogene Proteins c-met/antagonists & inhibitors; Proto-Oncogene Proteins c-met/drug effects; Proto-Oncogene Proteins c-met/genetics; Proto-Oncogene Proteins c-met/radiation effects; RNA, Messenger/metabolism; RNA, Small Interfering; Radiation Tolerance; Radiation, Ionizing; Radiation-Sensitizing Agents/pharmacology; Receptors, Growth Factor/drug effects; Receptors, Growth Factor/genetics; Receptors, Growth Factor/radiation effects; Sulfones/pharmacology; Transcription, Genetic/radiation effects; Transplantation, Heterologous; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/radiation effects; Up-Regulation/radiation effects

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Signal Transduction / NF-kappa B / Protein Serine-Threonine Kinases / Receptors, Growth Factor / Cell Cycle Proteins / Proto-Oncogene Proteins c-met / Tumor Suppressor Proteins / DNA-Binding Proteins / Neoplasms Language: En Journal: J Natl Cancer Inst Year: 2011 Document type: Article Affiliation country: Italy

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Signal Transduction / NF-kappa B / Protein Serine-Threonine Kinases / Receptors, Growth Factor / Cell Cycle Proteins / Proto-Oncogene Proteins c-met / Tumor Suppressor Proteins / DNA-Binding Proteins / Neoplasms Language: En Journal: J Natl Cancer Inst Year: 2011 Document type: Article Affiliation country: Italy