Involvement of PI3K/Akt/CREB and redox changes in mitochondrial defect of osteoblastic MC3T3-E1 cells.

Choi, Eun Mi; Lee, Young Soon

Choi, Eun Mi; Lee, Young Soon.

Affiliation

Choi EM; Department of Food and Nutrition, Kyung Hee University, 1, Hoegi-Dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea. cheunmi@hanmail.net

Toxicol In Vitro ; 25(5): 1085-8, 2011 Aug.

Article in En | MEDLINE | ID: mdl-21466842

Subject(s)

Antimycin A/pharmacology; Cyclic AMP Response Element-Binding Protein/metabolism; Kaempferols/pharmacology; Osteoblasts/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Animals; Catalase/analysis; Cell Line; Cell Survival; Cyclic AMP Response Element-Binding Protein/antagonists & inhibitors; Cyclic AMP Response Element-Binding Protein/genetics; Glutathione/analysis; Glutathione Peroxidase/analysis; Glutathione Reductase/analysis; Membrane Potential, Mitochondrial/drug effects; Mice; Mitochondria/metabolism; NAD/analysis; NADP/analysis; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases/genetics; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/genetics; Reactive Oxygen Species/metabolism; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Cyclic AMP Response Element-Binding Protein / Phosphatidylinositol 3-Kinases / Kaempferols / Proto-Oncogene Proteins c-akt / Antimycin A Limits: Animals Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2011 Document type: Article Country of publication: United kingdom

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