Synthesis of Hoodigogenin A, aglycone of natural appetite suppressant glycosteroids extracted from Hoodia gordonii.
Steroids
; 76(7): 702-8, 2011 Jun.
Article
in En
| MEDLINE
| ID: mdl-21473873
ABSTRACT
14ß-hydroxy pregnane glycosides extracted from Hoodia gordonii, a succulent plant isolated from Apocynaceae are suggested to have appetite suppressant properties in animals and humans. However, limited reports on biological studies concerning the appetite suppressant properties are available in the open literature. One reason for that is the poor availability of these glycosteroids because H. gordonii is a protected plant and the yield of extraction lies between 0.003% and 0.02%. Starting from 3α,12α-diacetoxy-pregnanone 1, we disclose in this report the synthesis of Hoodigogenin A, the aglycone of the natural 14ß-hydroxy pregnane glycosides extracted from H. Gordonii.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnanediol
/
Biological Products
/
Apocynaceae
/
Glycosides
Language:
En
Journal:
Steroids
Year:
2011
Document type:
Article
Affiliation country:
France