Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-ß-mediated growth inhibition.

Cohen-Solal, Karine A; Merrigan, Kim T; Chan, Joseph L-K; Goydos, James S; Chen, Wenjin; Foran, David J; Liu, Fang; Lasfar, Ahmed; Reiss, Michael

Cohen-Solal, Karine A; Merrigan, Kim T; Chan, Joseph L-K; Goydos, James S; Chen, Wenjin; Foran, David J; Liu, Fang; Lasfar, Ahmed; Reiss, Michael.

Affiliation

Cohen-Solal KA; Department of Medicine, Division of Medical Oncology, UMDNJ-Robert Wood Johnson Medical School, the Cancer Institute of New Jersey, New Brunswick, NJ, USA. cohenska@umdnj.edu

Pigment Cell Melanoma Res ; 24(3): 512-24, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21477078

Subject(s)

Melanoma/metabolism; Smad2 Protein/metabolism; Smad3 Protein/metabolism; Transforming Growth Factor beta/pharmacology; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p15/genetics; Cyclin-Dependent Kinase Inhibitor p15/metabolism; Cyclin-Dependent Kinase Inhibitor p21/genetics; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Drug Resistance, Neoplasm; Flavonoids/pharmacology; Humans; MAP Kinase Kinase 1/antagonists & inhibitors; MAP Kinase Kinase 1/genetics; MAP Kinase Kinase 1/metabolism; MAP Kinase Kinase 2/antagonists & inhibitors; MAP Kinase Kinase 2/genetics; MAP Kinase Kinase 2/metabolism; Melanoma/genetics; Melanoma/pathology; Mutation; Phosphorylation/drug effects; Phosphorylation/genetics; Piperidines/pharmacology; Protein Kinase Inhibitors/pharmacology; Protein Structure, Tertiary; Pyrimidines/pharmacology; Smad2 Protein/genetics; Smad3 Protein/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta / Smad2 Protein / Smad3 Protein / Melanoma Limits: Humans Language: En Journal: Pigment Cell Melanoma Res Journal subject: NEOPLASIAS Year: 2011 Document type: Article Affiliation country: United States

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