Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice.

Matsubara, Tsutomu; Tanaka, Naoki; Patterson, Andrew D; Cho, Joo-Youn; Krausz, Kristopher W; Gonzalez, Frank J

Matsubara, Tsutomu; Tanaka, Naoki; Patterson, Andrew D; Cho, Joo-Youn; Krausz, Kristopher W; Gonzalez, Frank J.

Affiliation

Matsubara T; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Hepatology ; 53(4): 1282-93, 2011 Apr.

Article in En | MEDLINE | ID: mdl-21480330

Subject(s)

Lithocholic Acid/toxicity; 1-Acylglycerophosphocholine O-Acyltransferase/biosynthesis; Animals; Ceramides/biosynthesis; Cholestasis; Female; Homeostasis/drug effects; Lithocholic Acid/blood; Lysophosphatidylcholines/blood; Metabolome; Mice; Mice, Inbred C57BL; Phospholipids/metabolism; RNA, Messenger/metabolism; Sphingolipids/metabolism; Sphingomyelin Phosphodiesterase/biosynthesis; Sphingomyelins/blood; Transforming Growth Factor beta/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lithocholic Acid Limits: Animals Language: En Journal: Hepatology Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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