Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover.

Milhollen, Michael A; Narayanan, Usha; Soucy, Teresa A; Veiby, Petter O; Smith, Peter G; Amidon, Benjamin

Milhollen, Michael A; Narayanan, Usha; Soucy, Teresa A; Veiby, Petter O; Smith, Peter G; Amidon, Benjamin.

Affiliation

Milhollen MA; Discovery, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA. Michael.Milhollen@MPI.com

Cancer Res ; 71(8): 3042-51, 2011 Apr 15.

Article in En | MEDLINE | ID: mdl-21487042

Subject(s)

Apoptosis/physiology; Cell Cycle Proteins/metabolism; DNA Replication; Ubiquitins/antagonists & inhibitors; Cell Line, Tumor; Cullin Proteins/antagonists & inhibitors; Cullin Proteins/genetics; Cullin Proteins/metabolism; Cyclopentanes/pharmacology; DNA Damage; DNA, Neoplasm/biosynthesis; Gene Knockdown Techniques; HCT116 Cells; Humans; NEDD8 Protein; Pyrimidines/pharmacology; RNA, Small Interfering/administration & dosage; RNA, Small Interfering/genetics; S Phase; Ubiquitins/genetics; Ubiquitins/metabolism

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitins / Apoptosis / Cell Cycle Proteins / DNA Replication Limits: Humans Language: En Journal: Cancer Res Year: 2011 Document type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google