Antibody response to preS1 in hepatitis-B-virus-induced liver disease and after immunization.
Res Virol
; 141(5): 563-70, 1990.
Article
in En
| MEDLINE
| ID: mdl-2148981
ABSTRACT
Antibodies to the pre-S1-encoded sequence of hepatitis B virus (HBV) envelope were detected by ELISA using a synthetic peptide analogue of preS1 proteins, in different groups of HBV-infected subjects and also in hepatitis B vaccine recipients. Such antibodies were specifically found in only 1% of HBsAg chronic carriers including patients with cirrhosis and primary liver cancer. Anti-preS1 were detected in patients with acute hepatitis; in 13% of the HBsAg+ sera obtained before recovery and in 37% of the sera obtained after recovery. Anti-preS1 antibodies were detected in recipients of a plasma-derived vaccine, but not in those receiving a recombinant vaccine. The results indicate that anti-preS1 is an earlier serum marker of HBV clearance than anti-preS2 and anti-S antibodies.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Precursors
/
Hepatitis B
/
Hepatitis B Antibodies
/
Hepatitis B Surface Antigens
Limits:
Adult
/
Child
/
Humans
Language:
En
Journal:
Res Virol
Journal subject:
VIROLOGIA
Year:
1990
Document type:
Article
Affiliation country:
France