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A mathematical model of human thymidine kinase 2 activity.
Radivoyevitch, T; Munch-Petersen, B; Wang, L; Eriksson, S.
Affiliation
  • Radivoyevitch T; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA. txr24@case.edu
Nucleosides Nucleotides Nucleic Acids ; 30(3): 203-9, 2011 Mar.
Article in En | MEDLINE | ID: mdl-21491329
The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymidine Kinase / Models, Theoretical Limits: Humans Language: En Journal: Nucleosides Nucleotides Nucleic Acids Journal subject: BIOQUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymidine Kinase / Models, Theoretical Limits: Humans Language: En Journal: Nucleosides Nucleotides Nucleic Acids Journal subject: BIOQUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States