KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.

Dolga, A M; Terpolilli, N; Kepura, F; Nijholt, I M; Knaus, H-G; D'Orsi, B; Prehn, J H M; Eisel, U L M; Plant, T; Plesnila, N; Culmsee, C

Dolga, A M; Terpolilli, N; Kepura, F; Nijholt, I M; Knaus, H-G; D'Orsi, B; Prehn, J H M; Eisel, U L M; Plant, T; Plesnila, N; Culmsee, C.

Affiliation

Dolga AM; Institut für Pharmakologie und Klinische Pharmazie, Fachbereich Pharmazie, Philipps-Universität Marburg, Marburg, Germany.

Cell Death Dis ; 2: e147, 2011 Apr 21.

Article in En | MEDLINE | ID: mdl-21509037

Subject(s)

Brain Ischemia/metabolism; Calcium Signaling; Glutamic Acid/metabolism; Neurons/physiology; Small-Conductance Calcium-Activated Potassium Channels/metabolism; Animals; Brain Ischemia/etiology; Brain Ischemia/pathology; Brain Ischemia/prevention & control; Cell Culture Techniques; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists/pharmacology; Glutamic Acid/toxicity; Indoles/pharmacology; Infarction, Middle Cerebral Artery/complications; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate/pharmacology; Neurons/drug effects; Neurons/pathology; Neuroprotective Agents/pharmacology; Oximes/pharmacology; Small-Conductance Calcium-Activated Potassium Channels/agonists; Small-Conductance Calcium-Activated Potassium Channels/genetics; Transcription, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Ischemia / Glutamic Acid / Calcium Signaling / Small-Conductance Calcium-Activated Potassium Channels / Neurons Type of study: Etiology_studies Limits: Animals Language: En Journal: Cell Death Dis Year: 2011 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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