Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
Endocr Pathol
; 22(2): 86-96, 2011 Jun.
Article
in En
| MEDLINE
| ID: mdl-21509594
ABSTRACT
Fine-needle aspiration biopsy (FNA) is currently the best initial diagnostic test for evaluation of a thyroid nodule. FNA cytology cannot discriminate between benign and malignant thyroid nodules in up to 30% of thyroid nodules. Therefore, an adjunct to FNA is needed to clarify these lesions as benign or malignant. Using differential display-polymerase chain reaction method, the gene expression differences between follicular and classic variants of papillary thyroid carcinoma (PTC) and benign thyroid nodules were evaluated in a group of 42 patients. Computational gene function analyses via Cytoscape, FuncBASE, and GeneMANIA led us to a functional network of 17 genes in which a core sub-network of five genes coexists. Although the exact mechanisms underlying in thyroid cancer biogenesis are not currently known, our data suggest that the pattern of transformation from healthy cells to cancer cells of PTC is different in follicular variant than in classic variant.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroid Neoplasms
/
Carcinoma, Papillary
/
Gene Expression Regulation, Neoplastic
/
Thyroid Nodule
/
Carcinoma, Papillary, Follicular
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Endocr Pathol
Journal subject:
ENDOCRINOLOGIA
/
PATOLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Turkey