Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction.

Putula, Jaana; Turunen, Pauli M; Johansson, Lisa; Näsman, Johnny; Ra, Runar; Korhonen, Laura; Kukkonen, Jyrki P

Putula, Jaana; Turunen, Pauli M; Johansson, Lisa; Näsman, Johnny; Ra, Runar; Korhonen, Laura; Kukkonen, Jyrki P.

Affiliation

Putula J; Biochemistry and Cell Biology, Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.

FEBS Lett ; 585(9): 1368-74, 2011 May 06.

Article in En | MEDLINE | ID: mdl-21510948

Subject(s)

Intracellular Signaling Peptides and Proteins/pharmacology; Neuropeptides/pharmacology; Receptors, G-Protein-Coupled/agonists; Receptors, Neuropeptide/agonists; Recombinant Fusion Proteins/agonists; Amino Acid Sequence; Binding Sites/genetics; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins/chemistry; Models, Molecular; Molecular Sequence Data; Mutation; Neuropeptides/chemistry; Orexin Receptors; Orexins; Protein Isoforms/agonists; Protein Isoforms/chemistry; Protein Isoforms/genetics; Protein Structure, Secondary; Receptors, G-Protein-Coupled/chemistry; Receptors, G-Protein-Coupled/genetics; Receptors, Neuropeptide/chemistry; Receptors, Neuropeptide/genetics; Recombinant Fusion Proteins/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptides / Recombinant Fusion Proteins / Receptors, Neuropeptide / Receptors, G-Protein-Coupled / Intracellular Signaling Peptides and Proteins Limits: Humans Language: En Journal: FEBS Lett Year: 2011 Document type: Article Affiliation country: Finland Country of publication: United kingdom

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