Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs.

Chen, Tian Sheng; Arslan, Fatih; Yin, Yijun; Tan, Soon Sim; Lai, Ruenn Chai; Choo, Andre Boon Hwa; Padmanabhan, Jayanthi; Lee, Chuen Neng; de Kleijn, Dominique P V; Lim, Sai Kiang

Chen, Tian Sheng; Arslan, Fatih; Yin, Yijun; Tan, Soon Sim; Lai, Ruenn Chai; Choo, Andre Boon Hwa; Padmanabhan, Jayanthi; Lee, Chuen Neng; de Kleijn, Dominique P V; Lim, Sai Kiang.

Affiliation

Chen TS; Institute of Medical Biology, A*STAR, 8A Biomedical Grove, 138648 Singapore.

J Transl Med ; 9: 47, 2011 Apr 25.

Article in En | MEDLINE | ID: mdl-21513579

Subject(s)

Cell Culture Techniques/methods; Cell Transformation, Neoplastic/pathology; Embryonic Stem Cells/pathology; Exosomes/metabolism; Mesenchymal Stem Cells/pathology; Animals; Antigens, Surface/metabolism; Cardiotonic Agents/metabolism; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Neoplastic/genetics; Gene Expression Profiling; Humans; Mesenchymal Stem Cells/metabolism; Mice; Proto-Oncogene Proteins c-myc/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Transformation, Neoplastic / Cell Culture Techniques / Embryonic Stem Cells / Exosomes / Mesenchymal Stem Cells Limits: Animals / Humans Language: En Journal: J Transl Med Year: 2011 Document type: Article Country of publication: United kingdom

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