MiADMSA reverses impaired mitochondrial energy metabolism and neuronal apoptotic cell death after arsenic exposure in rats.

Dwivedi, Nidhi; Mehta, Ashish; Yadav, Abhishek; Binukumar, B K; Gill, Kiran Dip; Flora, Swaran J S

Dwivedi, Nidhi; Mehta, Ashish; Yadav, Abhishek; Binukumar, B K; Gill, Kiran Dip; Flora, Swaran J S.

Affiliation

Dwivedi N; Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior-474 002, India.

Toxicol Appl Pharmacol ; 256(3): 241-8, 2011 Nov 01.

Article in En | MEDLINE | ID: mdl-21513725

Subject(s)

Apoptosis/drug effects; Arsenic Poisoning/drug therapy; Chelating Agents/pharmacology; Energy Metabolism/drug effects; Mitochondria/drug effects; Succimer/analogs & derivatives; Animals; Brain/cytology; Brain/drug effects; Brain/metabolism; Cells, Cultured; Electron Transport/drug effects; Electron Transport Complex IV/drug effects; Electron Transport Complex IV/metabolism; Male; Membrane Potential, Mitochondrial/drug effects; NADH Dehydrogenase/drug effects; NADH Dehydrogenase/metabolism; Neurons/drug effects; Neurons/metabolism; Oxidative Stress/drug effects; Rats; Rats, Wistar; Reactive Oxygen Species/analysis; Succimer/pharmacology; Succinate Dehydrogenase/drug effects; Succinate Dehydrogenase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chelating Agents / Apoptosis / Succimer / Arsenic Poisoning / Energy Metabolism / Mitochondria Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2011 Document type: Article Affiliation country: India Country of publication: United States

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