Apigenin attenuates dopamine-induced apoptosis in melanocytes via oxidative stress-related p38, c-Jun NH2-terminal kinase and Akt signaling.

Lin, Mao; Lu, Shan-Shan; Wang, Ao-Xue; Qi, Xiao-Yi; Zhao, Dan; Wang, Zhao-Hui; Man, Mao-Qiang; Tu, Cai-Xia

Lin, Mao; Lu, Shan-Shan; Wang, Ao-Xue; Qi, Xiao-Yi; Zhao, Dan; Wang, Zhao-Hui; Man, Mao-Qiang; Tu, Cai-Xia.

Affiliation

Lin M; Department of Dermatology, the 2nd Affiliated Hospital of Dalian Medical University, No.467 Zhongshan Road, Dalian 116027, Liaoning Province, PR China. lmsleeper@yahoo.com.cn

J Dermatol Sci ; 63(1): 10-6, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21514118

Subject(s)

Antioxidants/pharmacology; Apigenin/pharmacology; Apoptosis/drug effects; Dopamine/metabolism; JNK Mitogen-Activated Protein Kinases/metabolism; Melanocytes/drug effects; Oxidative Stress/drug effects; Proto-Oncogene Proteins c-akt/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism; Blotting, Western; Caspase 3/metabolism; Cell Survival/drug effects; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Humans; Melanocytes/enzymology; Melanocytes/pathology; Phosphorylation; Poly(ADP-ribose) Polymerases/metabolism; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Time Factors; Vitiligo/drug therapy; Vitiligo/enzymology; Vitiligo/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dopamine / Apoptosis / Oxidative Stress / Apigenin / JNK Mitogen-Activated Protein Kinases / P38 Mitogen-Activated Protein Kinases / Proto-Oncogene Proteins c-akt / Melanocytes / Antioxidants Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Dermatol Sci Journal subject: DERMATOLOGIA Year: 2011 Document type: Article Country of publication: Netherlands

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