Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis.

da Cunha-Júnior, Edézio Ferreira; Pacienza-Lima, Wallace; Ribeiro, Grazielle Alves; Netto, Chaquip Daher; do Canto-Cavalheiro, Marilene Marcuzzo; da Silva, Alcides José Monteiro; Costa, Paulo Roberto Ribeiro; Rossi-Bergmann, Bartira; Torres-Santos, Eduardo Caio

da Cunha-Júnior, Edézio Ferreira; Pacienza-Lima, Wallace; Ribeiro, Grazielle Alves; Netto, Chaquip Daher; do Canto-Cavalheiro, Marilene Marcuzzo; da Silva, Alcides José Monteiro; Costa, Paulo Roberto Ribeiro; Rossi-Bergmann, Bartira; Torres-Santos, Eduardo Caio.

Affiliation

da Cunha-Júnior EF; Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.

J Antimicrob Chemother ; 66(7): 1555-9, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21531758

Subject(s)

Antiprotozoal Agents/administration & dosage; Leishmaniasis, Cutaneous/drug therapy; Administration, Oral; Administration, Topical; Alanine Transaminase/blood; Animals; Antiprotozoal Agents/adverse effects; Antiprotozoal Agents/chemistry; Antiprotozoal Agents/pharmacology; Aspartate Aminotransferases/blood; Chemical and Drug Induced Liver Injury/diagnosis; Creatinine/blood; Disease Models, Animal; Inhibitory Concentration 50; Leishmania mexicana/drug effects; Leishmaniasis, Cutaneous/parasitology; Liver/enzymology; Mice; Mice, Inbred BALB C; Naphthoquinones/administration & dosage; Naphthoquinones/adverse effects; Naphthoquinones/chemistry; Naphthoquinones/pharmacology; Pterocarpans/administration & dosage; Pterocarpans/adverse effects; Pterocarpans/chemistry; Pterocarpans/pharmacology; Rodent Diseases/drug therapy; Rodent Diseases/parasitology; Serum/chemistry; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leishmaniasis, Cutaneous / Antiprotozoal Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: J Antimicrob Chemother Year: 2011 Document type: Article Affiliation country: Brazil Country of publication: United kingdom

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