Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.

Katuru, Rajasekhar; Fernandes, Nicolle V; Elfakhani, Manal; Dutta, Dibyendu; Mills, Nathaniel; Hynds, DiAnna L; King, Clay; Mo, Huanbiao

Katuru, Rajasekhar; Fernandes, Nicolle V; Elfakhani, Manal; Dutta, Dibyendu; Mills, Nathaniel; Hynds, DiAnna L; King, Clay; Mo, Huanbiao.

Affiliation

Katuru R; Department of Nutrition and Food Sciences, Texas Woman's University, Denton, 76204, USA.

Exp Biol Med (Maywood) ; 236(5): 604-13, 2011 May 01.

Article in En | MEDLINE | ID: mdl-21540247

Subject(s)

Diterpenes/pharmacology; Melanoma, Experimental/pathology; Mevalonic Acid/pharmacology; 3T3-L1 Cells; Alkaline Phosphatase/metabolism; Animals; Apoptosis/drug effects; Cell Cycle/drug effects; Cell Proliferation/drug effects; Cyclin D1/metabolism; Cyclin-Dependent Kinase 4/metabolism; Humans; Lovastatin/pharmacology; Melanoma, Experimental/enzymology; Mevalonic Acid/analogs & derivatives; Mice; Vitamin E/analogs & derivatives; Vitamin E/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Diterpenes / Mevalonic Acid Limits: Animals / Humans Language: En Journal: Exp Biol Med (Maywood) Journal subject: BIOLOGIA / FISIOLOGIA / MEDICINA Year: 2011 Document type: Article Affiliation country: United States

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