Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets.

Favre, D; Niederhauser, G; Fahmi, D; Plaisance, V; Brajkovic, S; Beeler, N; Allagnat, F; Haefliger, J A; Regazzi, R; Waeber, G; Abderrahmani, A

Favre, D; Niederhauser, G; Fahmi, D; Plaisance, V; Brajkovic, S; Beeler, N; Allagnat, F; Haefliger, J A; Regazzi, R; Waeber, G; Abderrahmani, A.

Affiliation

Favre D; Service of Internal Medicine, CHUV-Hospital, Lausanne, Switzerland.

Diabetologia ; 54(9): 2337-46, 2011 Sep.

Article in En | MEDLINE | ID: mdl-21547497

Subject(s)

Cyclic AMP Response Element Modulator/physiology; Insulin-Secreting Cells/physiology; Islets of Langerhans/physiopathology; Oxidative Stress/physiology; Acetylcysteine/pharmacology; Animals; Antioxidants/pharmacology; Apoptosis/drug effects; Cells, Cultured; Cyclic AMP Response Element Modulator/drug effects; Cyclic AMP Response Element Modulator/genetics; Humans; Hydrogen Peroxide/pharmacology; Insulin/metabolism; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/drug effects; Islets of Langerhans/cytology; Islets of Langerhans/drug effects; Lipoproteins, LDL/pharmacology; Male; Models, Animal; Oxidative Stress/drug effects; RNA, Small Interfering/pharmacology; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Islets of Langerhans / Oxidative Stress / Insulin-Secreting Cells / Cyclic AMP Response Element Modulator Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Diabetologia Year: 2011 Document type: Article Affiliation country: Switzerland

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