Anxiolytic-like effect of oxytocin in the simulated public speaking test.
J Psychopharmacol
; 26(4): 497-504, 2012 Apr.
Article
in En
| MEDLINE
| ID: mdl-21555332
ABSTRACT
Oxytocin (OT) is known to be involved in anxiety, as well as cardiovascular and hormonal regulation. The objective of this study was to assess the acute effect of intranasally administered OT on subjective states, as well as cardiovascular and endocrine parameters, in healthy volunteers (n = 14) performing a simulated public speaking test. OT or placebo was administered intranasally 50 min before the test. Assessments were made across time during the experimental session (1) baseline (-30 min); (2) pre-test (-15 min); (3) anticipation of the speech (50 min); (4) during the speech (103 h), post-test time 1 (126 h), and post-test time 2 (146 h). Subjective states were evaluated by self-assessment scales. Cortisol serum and plasma adrenocorticotropic hormone (ACTH) were measured. Additionally, heart rate, blood pressure, skin conductance, and the number of spontaneous fluctuations in skin conductance were measured. Compared with placebo, OT reduced the Visual Analogue Mood Scale (VAMS) anxiety index during the pre-test phase only, while increasing sedation at the pre-test, anticipation, and speech phases. OT also lowered the skin conductance level at the pre-test, anticipation, speech, and post-test 2 phases. Other parameters evaluated were not significantly affected by OT. The present results show that OT reduces anticipatory anxiety, but does not affect public speaking fear, suggesting that this hormone has anxiolytic properties.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Speech
/
Anti-Anxiety Agents
/
Oxytocin
Type of study:
Clinical_trials
Limits:
Adult
/
Humans
Language:
En
Journal:
J Psychopharmacol
Journal subject:
PSICOFARMACOLOGIA
Year:
2012
Document type:
Article
Affiliation country:
Brazil