A calcineurin-independent mechanism of angiogenesis inhibition by a nonimmunosuppressive cyclosporin A analog.

Nacev, Benjamin A; Low, Woon-Kai; Huang, Zhennian; Su, Tina T; Su, Zhuang; Alkuraya, Hisham; Kasuga, Dan; Sun, Woong; Träger, Mario; Braun, Manfred; Fischer, Gunter; Zhang, Kang; Liu, Jun O

Nacev, Benjamin A; Low, Woon-Kai; Huang, Zhennian; Su, Tina T; Su, Zhuang; Alkuraya, Hisham; Kasuga, Dan; Sun, Woong; Träger, Mario; Braun, Manfred; Fischer, Gunter; Zhang, Kang; Liu, Jun O.

Affiliation

Nacev BA; Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205, USA.

J Pharmacol Exp Ther ; 338(2): 466-75, 2011 Aug.

Article in En | MEDLINE | ID: mdl-21562139

Subject(s)

Angiogenesis Inhibitors/chemistry; Angiogenesis Inhibitors/metabolism; Calcineurin/metabolism; Cyclosporine/chemistry; Cyclosporine/metabolism; Immunosuppressive Agents; Angiogenesis Inhibitors/pharmacology; Animals; Calcineurin Inhibitors; Cell Proliferation/drug effects; Cells, Cultured; Cyclosporine/pharmacology; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Humans; Immunosuppressive Agents/chemistry; Immunosuppressive Agents/metabolism; Immunosuppressive Agents/pharmacology; Jurkat Cells; Male; Mice; Mice, Inbred C57BL; Mice, Nude

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclosporine / Calcineurin / Angiogenesis Inhibitors / Immunosuppressive Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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