Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement.

Sun, Xicheng; Qiu, Jian; Strong, Sarah A; Green, Louis S; Wasley, Jan W F; Colagiovanni, Dorothy B; Mutka, Sarah C; Blonder, Joan P; Stout, Adam M; Richards, Jane P; Chun, Lawrence; Rosenthal, Gary J

Sun, Xicheng; Qiu, Jian; Strong, Sarah A; Green, Louis S; Wasley, Jan W F; Colagiovanni, Dorothy B; Mutka, Sarah C; Blonder, Joan P; Stout, Adam M; Richards, Jane P; Chun, Lawrence; Rosenthal, Gary J.

Affiliation

Sun X; N30 Pharmaceuticals LLC, Boulder, CO 80301, USA. xicheng.sun@n30pharma.com

Bioorg Med Chem Lett ; 21(12): 3671-5, 2011 Jun 15.

Article in En | MEDLINE | ID: mdl-21570838

Subject(s)

Aldehyde Oxidoreductases/antagonists & inhibitors; Benzamides/chemistry; Benzamides/pharmacology; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Propionates/chemistry; Propionates/pharmacology; Pyrroles/chemistry; Pyrroles/pharmacology; Benzamides/chemical synthesis; Enzyme Activation/drug effects; Enzyme Inhibitors/chemical synthesis; Inhibitory Concentration 50; Molecular Structure; Propionates/chemical synthesis; Pyrroles/chemical synthesis; Stereoisomerism; Structure-Activity Relationship

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propionates / Pyrroles / Benzamides / Aldehyde Oxidoreductases / Enzyme Inhibitors Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google