Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.

Furman, Phillip A; Murakami, Eisuke; Niu, Congrong; Lam, Angela M; Espiritu, Christine; Bansal, Shalini; Bao, Haiying; Tolstykh, Tatiana; Micolochick Steuer, Holly; Keilman, Meg; Zennou, Veronique; Bourne, Nigel; Veselenak, Ronald L; Chang, Wonsuk; Ross, Bruce S; Du, Jinfa; Otto, Michael J; Sofia, Michael J

Furman, Phillip A; Murakami, Eisuke; Niu, Congrong; Lam, Angela M; Espiritu, Christine; Bansal, Shalini; Bao, Haiying; Tolstykh, Tatiana; Micolochick Steuer, Holly; Keilman, Meg; Zennou, Veronique; Bourne, Nigel; Veselenak, Ronald L; Chang, Wonsuk; Ross, Bruce S; Du, Jinfa; Otto, Michael J; Sofia, Michael J.

Affiliation

Furman PA; Pharmasset, Inc., Princeton, NJ 08540, USA. phillip.furman@pharmasset.com

Antiviral Res ; 91(2): 120-32, 2011 Aug.

Article in En | MEDLINE | ID: mdl-21600932

Subject(s)

Antiviral Agents/pharmacology; Guanosine Monophosphate/analogs & derivatives; Hepacivirus/drug effects; Prodrugs/pharmacology; Virus Replication/drug effects; Biotransformation; Cathepsin A/metabolism; Chromatography, High Pressure Liquid; Cloning, Molecular; Drug Evaluation, Preclinical; Guanosine Monophosphate/antagonists & inhibitors; Guanosine Monophosphate/pharmacology; Guanylate Kinases/metabolism; Hep G2 Cells; Hepacivirus/genetics; Hepacivirus/physiology; Hepatocytes/drug effects; Humans; Lactic Acid/metabolism; Luciferases/metabolism; Microbial Sensitivity Tests; Mitochondria/drug effects; Mitochondria/metabolism; Mutation; Nerve Tissue Proteins/metabolism; Phenol/metabolism; Phosphorylation; Prodrugs/chemistry; Replicon; Viral Nonstructural Proteins/antagonists & inhibitors

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Virus Replication / Prodrugs / Guanosine Monophosphate / Hepacivirus Limits: Humans Language: En Journal: Antiviral Res Year: 2011 Document type: Article Affiliation country: United States Country of publication: Netherlands

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google