Endothelial Cells/pathology; Proteasome Endopeptidase Complex/metabolism; Ubiquitin/metabolism; Uremia/blood; Animals; Apoptosis/drug effects; Cell Cycle/drug effects; Cell Nucleus/metabolism; Cell Proliferation/drug effects; Cells, Cultured; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Inflammation/genetics; Inflammation/metabolism; Leupeptins/pharmacology; NF-kappa B/antagonists & inhibitors; NF-kappa B/genetics; NF-kappa B/metabolism; Nitric Oxide/metabolism; Proteasome Inhibitors; Protein Binding/drug effects; Protein Transport/drug effects; Pyrrolidines/pharmacology; Rabbits; Signal Transduction/drug effects; Thiocarbamates/pharmacology; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism; Ubiquitin-Activating Enzymes/genetics; Ubiquitin-Activating Enzymes/metabolism; Uremia/pathology