[Emerging key role of cell cycle regulators in cell metabolism]. / Le double jeu des régulateurs du cycle cellulaire: contrôle de la prolifération et du métabolisme.
Med Sci (Paris)
; 27(5): 508-13, 2011 May.
Article
in Fr
| MEDLINE
| ID: mdl-21609672
ABSTRACT
The role of cell cycle regulators in the control of cell proliferation has been extensively studied, but independently of these functions in cell proliferation, it now appears that these proteins are also key to the adapted metabolic response of the cells. This has some logic since cell cycle is linked to metabolic control. This review focusses on the involvment of cyclins, cyclin dependent kinases or E2F factor in the control of adipogenesis, glucidic homeostasis, and energy consumption. Murine models in which genes encoding these regulators have been invalidated have been key to unravel these novel functions of cell cycle regulators in cell metabolism. Furthermore, these findings may also have some relevance for metabolic disorders such as obesity or diabetes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cells
/
Cell Cycle Proteins
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
Fr
Journal:
Med Sci (Paris)
Journal subject:
MEDICINA
Year:
2011
Document type:
Article
Affiliation country:
France
Country of publication:
FR
/
FRANCE
/
FRANCIA
/
FRANÇA