Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K.

Suhara, Yoshitomo; Watanabe, Masato; Motoyoshi, Sayaka; Nakagawa, Kimie; Wada, Akimori; Takeda, Kazuyoshi; Takahashi, Kazuhiko; Tokiwa, Hiroaki; Okano, Toshio

Suhara, Yoshitomo; Watanabe, Masato; Motoyoshi, Sayaka; Nakagawa, Kimie; Wada, Akimori; Takeda, Kazuyoshi; Takahashi, Kazuhiko; Tokiwa, Hiroaki; Okano, Toshio.

Affiliation

Suhara Y; Laboratory of Environmental Sciences, Yokohama College of Pharmacy, Totsuka-ku, Yokohama, Japan.

J Med Chem ; 54(13): 4918-22, 2011 Jul 14.

Article in En | MEDLINE | ID: mdl-21618996

Subject(s)

Receptors, Steroid/agonists; Vitamin K/analogs & derivatives; Vitamin K/chemical synthesis; Binding Sites; Butadienes/chemical synthesis; Butadienes/chemistry; Butadienes/pharmacology; Genes, Reporter; Hemiterpenes/chemical synthesis; Hemiterpenes/chemistry; Hemiterpenes/pharmacology; Hep G2 Cells; Humans; Ligands; Luciferases/biosynthesis; Luciferases/genetics; Pentanes/chemical synthesis; Pentanes/chemistry; Pentanes/pharmacology; Pregnane X Receptor; Receptors, Steroid/genetics; Structure-Activity Relationship; Transcription, Genetic/drug effects; Vitamin K/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vitamin K / Receptors, Steroid Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2011 Document type: Article Affiliation country: Japan Country of publication: United States

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