Mode of delivery and neonatal respiratory morbidity among HIV-exposed newborns in Latin America and the Caribbean: NISDI Perinatal-LILAC Studies.
Int J Gynaecol Obstet
; 114(2): 91-6, 2011 Aug.
Article
in En
| MEDLINE
| ID: mdl-21620404
ABSTRACT
OBJECTIVE:
To evaluate respiratory morbidity (RM) in HIV-exposed newborns according to mode of delivery.METHODS:
The NISDI Perinatal/LILAC prospective cohort studies enrolled HIV-infected pregnant women and their newborns in Latin America and the Caribbean. Associations between RM and delivery mode or other characteristics were evaluated.RESULTS:
Between September 2002 and December 2009, 1630 women were enrolled, and 1443 mother-infant pairs met the inclusion criteria. There were 561 vaginal (VD), 269 cesarean before labor and membrane rupture (SCS) for preventing mother-to-child transmission (SCS-PMTCT), 248 other SCS, and 365 cesarean after labor and/or ruptured membranes (NSCS) deliveries. In total, 108 (7.5%) newborns had RM 49 had respiratory distress syndrome (RDS), 39 had transient tachypnea (TTN), and 28 had other events (7 newborns had >1 RM event). Delivery mode was associated with RDS (P<0.005) and TTN (P<0.001). The proportion with RDS and TTN was lowest for VD (1.6% and 0.5%, respectively), highest for NSCS (4.9% and 4.7%), and intermediate for SCS-PMTCT (3.0% and 2.6%). Newborns with RDS or TTN were hospitalized longer (median +1day) than those without. A minority required ventilatory support (RDS, 24.5%-28.6%; TTN, 2.6%-15.4%).CONCLUSIONS:
SCS-PMTCT is relatively safe for newborns of HIV-infected women.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Respiratory Distress Syndrome, Newborn
/
Respiratory Tract Diseases
/
HIV Infections
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Delivery, Obstetric
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Maternal-Fetal Exchange
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
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Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Language:
En
Journal:
Int J Gynaecol Obstet
Year:
2011
Document type:
Article
Affiliation country:
Brazil