Upregulation of hypoxia-inducible factor 1 alpha in local vein wall is associated with enhanced venous thrombus resolution.

Evans, Colin E; Humphries, Julia; Waltham, Matthew; Saha, Prakash; Mattock, Katherine; Patel, Ashish; Ahmad, Anwar; Wadoodi, Ashar; Modarai, Bijan; Burnand, Kevin; Smith, Alberto

Evans, Colin E; Humphries, Julia; Waltham, Matthew; Saha, Prakash; Mattock, Katherine; Patel, Ashish; Ahmad, Anwar; Wadoodi, Ashar; Modarai, Bijan; Burnand, Kevin; Smith, Alberto.

Affiliation

Evans CE; Academic Department of Surgery, Cardiovascular Division, King's College London, BHF Centre of Excellence, NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, United Kingdom.

Thromb Res ; 128(4): 346-51, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21621825

Subject(s)

Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Vena Cava, Inferior/metabolism; Venous Thrombosis/metabolism; Animals; Disease Models, Animal; Enzyme Inhibitors/pharmacology; Male; Mice; Mice, Inbred BALB C; Mimosine/pharmacology; Neovascularization, Physiologic; Placenta Growth Factor; Pregnancy Proteins/metabolism; Procollagen-Proline Dioxygenase/antagonists & inhibitors; Procollagen-Proline Dioxygenase/metabolism; Time Factors; Up-Regulation; Vascular Endothelial Growth Factor A/metabolism; Vena Cava, Inferior/drug effects; Vena Cava, Inferior/pathology; Venous Thrombosis/drug therapy; Venous Thrombosis/pathology; Venous Thrombosis/physiopathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vena Cava, Inferior / Venous Thrombosis / Hypoxia-Inducible Factor 1, alpha Subunit Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Thromb Res Year: 2011 Document type: Article Affiliation country: United kingdom Country of publication: United States

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