Pleiotropic and age-dependent effects of decreased protein modification by O-linked N-acetylglucosamine on pancreatic ß-cell function and vascularization.

Soesanto, Yudi; Luo, Bai; Parker, Glendon; Jones, Deborah; Cooksey, Robert C; McClain, Donald A

Soesanto, Yudi; Luo, Bai; Parker, Glendon; Jones, Deborah; Cooksey, Robert C; McClain, Donald A.

Affiliation

Soesanto Y; Departments of Biochemistry, University of Utah School ofMedicine, Salt Lake City, Utah 84132, USA.

J Biol Chem ; 286(29): 26118-26, 2011 Jul 22.

Article in En | MEDLINE | ID: mdl-21622566

Subject(s)

Acetylglucosamine/metabolism; Aging/metabolism; Genetic Pleiotropy; Insulin-Secreting Cells/cytology; Neovascularization, Physiologic/genetics; Oxygen; Protein Processing, Post-Translational/genetics; Acetylglucosamine/biosynthesis; Acetylglucosamine/chemistry; Aging/genetics; Aging/physiology; Animals; Female; Glucose Tolerance Test; Humans; Insulin/biosynthesis; Insulin/genetics; Insulin/metabolism; Insulin Secretion; Insulin-Secreting Cells/enzymology; Insulin-Secreting Cells/metabolism; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic/genetics; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Signal Transduction/genetics; Time Factors; beta-N-Acetylhexosaminidases/genetics; beta-N-Acetylhexosaminidases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Acetylglucosamine / Aging / Protein Processing, Post-Translational / Neovascularization, Physiologic / Insulin-Secreting Cells / Genetic Pleiotropy Limits: Animals / Female / Humans / Male Language: En Journal: J Biol Chem Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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