Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase.

Teng, Ru-Jeng; Du, Jianhai; Xu, Hao; Bakhutashvili, Ivane; Eis, Annie; Shi, Yang; Pritchard, Kirkwood A; Konduri, Girija G

Teng, Ru-Jeng; Du, Jianhai; Xu, Hao; Bakhutashvili, Ivane; Eis, Annie; Shi, Yang; Pritchard, Kirkwood A; Konduri, Girija G.

Affiliation

Teng RJ; Division of Neonatology, Dept. of Pediatrics, Medical College of Wisconsin, Suite C410, Children Corporate Center, 999N 92nd St., Wauwatosa, WI 53226, USA. rteng@mcw.edu

Am J Physiol Lung Cell Mol Physiol ; 301(3): L334-45, 2011 Sep.

Article in En | MEDLINE | ID: mdl-21622842

Subject(s)

Nitric Oxide Synthase Type III/metabolism; Pterins/pharmacology; Animals; Apoptosis/drug effects; Biopterins/analogs & derivatives; Biopterins/metabolism; Cell Movement/drug effects; Endothelium, Vascular/metabolism; GTP Cyclohydrolase/biosynthesis; HSP90 Heat-Shock Proteins/metabolism; Humans; Infant, Newborn; Neovascularization, Physiologic/drug effects; Nitric Oxide Synthase Type III/drug effects; Persistent Fetal Circulation Syndrome; Protein Multimerization/drug effects; Sheep, Domestic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pterins / Nitric Oxide Synthase Type III Limits: Animals / Humans / Newborn Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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