AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.

Johnson, Jarrod S; Gentzsch, Martina; Zhang, Liqun; Ribeiro, Carla M P; Kantor, Boris; Kafri, Tal; Pickles, Raymond J; Samulski, R Jude

Johnson, Jarrod S; Gentzsch, Martina; Zhang, Liqun; Ribeiro, Carla M P; Kantor, Boris; Kafri, Tal; Pickles, Raymond J; Samulski, R Jude.

Affiliation

Johnson JS; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America. rjs@med.unc.edu

PLoS Pathog ; 7(5): e1002053, 2011 May.

Article in En | MEDLINE | ID: mdl-21625534

Subject(s)

Cystic Fibrosis Transmembrane Conductance Regulator/chemistry; Cystic Fibrosis/metabolism; Dependovirus/metabolism; Dependovirus/pathogenicity; Endoplasmic Reticulum/metabolism; Parvoviridae Infections/metabolism; Animals; Cell Line; Cricetinae; Cystic Fibrosis/genetics; Cystic Fibrosis Transmembrane Conductance Regulator/genetics; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; Disease Susceptibility; Flow Cytometry; HeLa Cells; Humans; Inflammation; Lung; Mesocricetus; Microtubule-Organizing Center/metabolism; Mutation; Polymerase Chain Reaction; Protein Folding; RNA Interference; RNA, Small Interfering; Stress, Physiological

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dependovirus / Parvoviridae Infections / Cystic Fibrosis Transmembrane Conductance Regulator / Cystic Fibrosis / Endoplasmic Reticulum Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: PLoS Pathog Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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