Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design.

Mineharu, Yohei; King, Gwendalyn D; Muhammad, A K M G; Bannykh, Serguei; Kroeger, Kurt M; Liu, Chunyan; Lowenstein, Pedro R; Castro, Maria G

Mineharu, Yohei; King, Gwendalyn D; Muhammad, A K M G; Bannykh, Serguei; Kroeger, Kurt M; Liu, Chunyan; Lowenstein, Pedro R; Castro, Maria G.

Affiliation

Mineharu Y; Gene Therapeutics Research Institute, Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

Clin Cancer Res ; 17(14): 4705-18, 2011 Jul 15.

Article in En | MEDLINE | ID: mdl-21632862

Subject(s)

Brain Neoplasms/therapy; Cancer Vaccines/therapeutic use; Dendritic Cells/immunology; Glioblastoma/therapy; Tumor Microenvironment/immunology; Adenoviridae/genetics; Animals; Brain Neoplasms/genetics; Brain Neoplasms/immunology; Cancer Vaccines/immunology; Cell Death/immunology; Cell Line, Tumor; Clinical Trials as Topic; Cytokines/metabolism; Dendritic Cells/transplantation; Disease Models, Animal; Gene Expression Regulation, Viral; Genetic Therapy; Genetic Vectors/genetics; Glioblastoma/genetics; Glioblastoma/immunology; Rats; Thymidine Kinase/genetics; Thymidine Kinase/metabolism; Tumor Microenvironment/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Brain Neoplasms / Glioblastoma / Cancer Vaccines / Tumor Microenvironment Type of study: Prognostic_studies Limits: Animals Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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