Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles.

Loudin, M G; Wang, J; Leung, H-C Eastwood; Gurusiddappa, S; Meyer, J; Condos, G; Morrison, D; Tsimelzon, A; Devidas, M; Heerema, N A; Carroll, A J; Plon, S E; Hunger, S P; Basso, G; Pession, A; Bhojwani, D; Carroll, W L; Rabin, K R

Loudin, M G; Wang, J; Leung, H-C Eastwood; Gurusiddappa, S; Meyer, J; Condos, G; Morrison, D; Tsimelzon, A; Devidas, M; Heerema, N A; Carroll, A J; Plon, S E; Hunger, S P; Basso, G; Pession, A; Bhojwani, D; Carroll, W L; Rabin, K R.

Affiliation

Loudin MG; Division of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Leukemia ; 25(10): 1555-63, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21647151

Subject(s)

DNA Methylation; Down Syndrome/genetics; Gene Deletion; Gene Expression Profiling; Histones/genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics; Base Sequence; DNA Primers; Down Syndrome/complications; Humans; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications; Real-Time Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / Gene Deletion / Down Syndrome / DNA Methylation / Gene Expression Profiling / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

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