The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.

Luo, Biquan; Lam, Ben S; Lee, Sung Hyung; Wey, Shiuan; Zhou, Hui; Wang, Miao; Chen, Si-Yi; Adams, Gregor B; Lee, Amy S

Luo, Biquan; Lam, Ben S; Lee, Sung Hyung; Wey, Shiuan; Zhou, Hui; Wang, Miao; Chen, Si-Yi; Adams, Gregor B; Lee, Amy S.

Affiliation

Luo B; Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.

PLoS One ; 6(5): e20364, 2011.

Article in En | MEDLINE | ID: mdl-21647226

Subject(s)

Bone Marrow Cells/cytology; Cell Communication; Endoplasmic Reticulum/metabolism; HSP70 Heat-Shock Proteins/metabolism; Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/metabolism; Membrane Proteins/metabolism; Stem Cell Niche/cytology; Animals; Cell Communication/genetics; Cell Differentiation/genetics; Cell Movement/genetics; Female; Fibronectins/metabolism; Gene Expression Regulation/genetics; Gene Knockout Techniques; HSP70 Heat-Shock Proteins/deficiency; HSP70 Heat-Shock Proteins/genetics; Homeostasis/genetics; Integrin alpha4/metabolism; Lymphocytes/cytology; Male; Membrane Proteins/deficiency; Membrane Proteins/genetics; Mice; Myeloid Cells/cytology; Resting Phase, Cell Cycle/genetics; Stem Cell Niche/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow Cells / Hematopoietic Stem Cells / Cell Communication / HSP70 Heat-Shock Proteins / Endoplasmic Reticulum / Stem Cell Niche / Membrane Proteins Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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