Synthesis and biological activity of chiral dihydropyrazole: potential lead for drug design.
Mini Rev Med Chem
; 11(9): 771-821, 2011 Aug.
Article
in En
| MEDLINE
| ID: mdl-21651464
ABSTRACT
Dihydropyrazole, a small bioactive molecule, is a prominent structural motif found in numerous pharmaceutically active compounds. The chiral dihydropyrazole structure has been demonstrated to bear important biological activities such as anticancer, antimicrobial, antimalarial, antinociceptive, antiviral, antitubercular, antiinflammatory, anticonvulsant and steroidal, and can also act as MAO inhibitors, CB1 receptor antagonists and nitric oxide synthase inhibitors. The review describes the latest advances in the synthesis of dihydropyrazole derivatives incorporating physiologically active substances. It is the first attempt at a general and systematic account of the extensive literature data on this subject.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrazoles
/
Drug Design
Language:
En
Journal:
Mini Rev Med Chem
Journal subject:
QUIMICA
Year:
2011
Document type:
Article